Chromosomal instability as an architect of the cancer stemness landscape

Chromosomal instability as an architect of the cancer stemness landscape

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Despite a critical role for tumor-initiating cancer stem cells (CSCs) in breast cancer progression, major questions remain about the properties and signaling pathways essential for their function.Recent discoveries highlighting mechanisms of CSC-resistance to the stress caused by chromosomal instability (CIN) may provide valuable new insight into the underlying forces driving stemness properties.While stress tolerance is a well-known attribute of CSCs, CIN-induced stress is distinctive since levels appear to increase during edgewater shoes tumor initiation and metastasis.These dynamic changes in CIN levels may serve as a barrier constraining the effects of non-CSCs and shaping the stemness landscape during the early stages of disease progression.

In contrast to most other iphone 13 pro max price florida stresses, CIN can also paradoxically activate pro-tumorigenic antiviral signaling.Though seemingly contradictory, this may indicate that mechanisms of CIN tolerance and pro-tumorigenic inflammatory signaling closely collaborate to define the CSC state.Together, these unique features may form the basis for a critical relationship between CIN and stemness properties.